Firstly, you need to understand what your employees really want. If they prefer a higher salary, the option granted to him/her shall not have desired incentive effect.
Secondly, you need to think about to what levels of employees you should grant how many quantities of options. Top management, for example, may prefer more options and therefore larger grants to them may effectively improve your business performance.
Thirdly, you may need to consider when and how your employees can exercise the options since there are difference tax implications depending on when they exercise.